Help us overcome PLN
Our mission is to find an affordable treatment for the genetic heart muscle disease PLN. As a foundation, we fund scientific research and bring scientists together. Additionally, we aim to connect individuals with PLN, raise awareness about PLN, and provide support to affected families.
Here's how we assist you:
Carriers
We provide carriers with the necessary information about PLN to better understand the implications of the disease.
Support Group
We facilitate the connection between individuals affected by PLN through an online Facebook community and physical gatherings.
Family and Friends
If you are closely connected to someone with the PLN gene or may be a carrier yourself, we offer the right information and support.
About PLN
What is PLN exactly?
To make our hearts beat, calcium ions are crucial in the heart muscle cells. The protein phospholamban (PLN) plays a significant role in the calcium balance of these cells. In 2010, a mutation (genetic change) in the PLN gene was linked to the development of a heart muscle disease in the Netherlands. The Dutch mutation involves the absence of the amino acid arginine (Arg) at position 14, and is therefore scientifically referred to as: PLN p.Arg14del (1).
Take action for PLN
We create a world without PLN together. By funding scientific research, connecting researchers, and ultimately bringing an affordable treatment to carriers. However, scientific research takes time, money, and energy. To continuously finance research, carriers and their loved ones help us by raising donations.
Ride along and raise money for PLN research during Vuelta in Utrecht 2025! 🚴
On Sunday, August 31, 2025, Vuelta a Utrecht will take place. This is a tour in Spanish spheres, on Dutch soil. A wonderful moment when
Martin de Boer drummed up network for a bike day and bike ride: “The reactions were hugely stimulating.”
Every year Martin de Boer organizes together with a few enthusiasts from the cycling group 50+, organizes a sponsor bicycle tour. Through an all-inclusive concept,
Best friends Alice & Nikki run for PLN!
Every month, committed supporters and loved ones start actions on our dedicated fundraising website. All money raised through this website is 100% dedicated to scientific
Stay Informed
We send an email approximately once a month to those who want to stay updated about developments concerning the foundation and PLN. We discuss events, informational sessions, and updates on PLN research.
Blog
Our latest news
Discover more about ongoing initiatives, involved volunteers, and scientific advancements.
I-1c: A potential treatment for PLN-R14del becomes available to patients in clinical trials
The mission of the PLN Foundation is crystal clear: to find a safe, affordable and effective treatment for PLN R14del. A new development may offer
Ride along and raise money for PLN research during Vuelta in Utrecht 2025! 🚴
On Sunday, August 31, 2025, Vuelta a Utrecht will take place. This is a tour in Spanish spheres, on Dutch soil. A wonderful moment when
Join research for guidance before, during and after pregnancy for female carriers of the PLN mutation
For this study, the UMCG (UMC Groningen) is asking for help from women who are carriers of the PLN gene mutation (p.(Arg14del) variant). With this