Information
PLN Foundation provides a lot of on- and offline information about PLN-R14del. That way you are always up to date.
Carriers
Are you a carrier of the PLN mutation? Then there can be a lot to deal with. We help you with the right information, peer contact and research.
Research
We fund scientific research and bring scientists worldwide together to take action for PLN-R14del.
PLN-R14del
Invisible,
but life-size
For our heart to beat, calcium ions are important. This is a small protein in the heart muscle cell. The protein phospholamban (PLN) has an important role in the calcium metabolism of heart muscle cells. A change in the PLN gene, or mutation, prevents certain proteins from being made properly. This can have an effect on heart muscle function. When this effect occurs, symptoms such as arrhythmias, chest pain, shortness of breath and dizziness may occur.
A race against the clock
PLN-R14del is a race against the clock. Many carriers of the PLN mutation do not know they are carriers. So they walk around with a ticking time bomb. Because when the heart stops beating, the consequences are dire. That’s why on Sunday, September 14, 2025, we will compete in a race against the clock. With the Ticking Clock Challenge, you choose your sporting challenge. Take part in the Slow Marathon (for recreational walkers) or the Fast Double Marathon (for fanatical runners) on the iconic Circuit Zandvoort!
our objective
Our mission
The PLN Foundation was founded in 2012 by chairman Pieter Glijnis. As a PLN patient, he experienced firsthand how heartbreaking the disease is. After a heart transplant, he decided to use this second life given to him for a mission: to find a safe and affordable treatment for the heart muscle disease PLN-R14del.
Dot on
the horizon
Over the next 10 years we have the goal of raising 1 million euros in funds each year. This totals 10 million euros. This amount plays an important role in bringing treatment from the laboratory to the patient.
€ 0,-
€ 10.000.000,-
On the agenda
Meet us at our on- and offline events for wearers, loved ones and other interested parties.
Latest News
Discover our latest updates first
The mission of the PLN Foundation is crystal clear: to find a safe, affordable and effective treatment for PLN R14del. A new development may offer hope: the experimental drug I-1c, a gene therapy currently being tested in several heart patients,
On Sunday, August 31, 2025, Vuelta a Utrecht will take place. This is a tour in Spanish spheres, on Dutch soil. A wonderful moment when the Netherlands Heart Institute team will be cycling to raise money for research into PLN.
For this study, the UMCG (UMC Groningen) is asking for help from women who are carriers of the PLN gene mutation (p.(Arg14del) variant). With this research they want to learn more about the wishes and preferences of counseling before, during