Read here the thesis of Sam Biermans, a Biomedical Sciences student at Utrecht University. Under the guidance of Dr. Niels Bovenschen, Sam Biermans wrote her thesis on the current developments in virus therapy for PLN patients. It is a very clear, in-depth, and informative thesis for those interested.
Her thesis mainly focuses on the adeno-associated virus; how does the virus normally work, and how can it be modified into a gene delivery vehicle. Then, it delves into the PLN R14del disease and how the recombinant AAV virus could potentially provide new therapies.
With permission from Sam Biermans, you can download it here: Research project_SamBiermans.