GIP – Lesson 4: Existing gene therapies.
With GIP (gene therapy information packet), we take you into the world of gene therapy. In recent years there has been a lot of research into gene therapy. This has…
BIP – Lesson 3: Risks and concerns.
With GIP (gene therapy information packet), we take you into the world of gene therapy. In recent years there has been a lot of research into gene therapy. This has…
BIP – Lesson 2: Possible gene therapies.
With GIP (gene therapy information packet), we take you into the world of gene therapy. In recent years there has been a lot of research into gene therapy. This has…
BIP – Lesson 1: Cells and DNA.
With GIP (gene therapy information packet), we take you into the world of gene therapy. In recent years there has been a lot of research into gene therapy. This has…
The PLN Mouse Heart II: Tickak tikKRAK, how problems in a PLN heart can lead to arrhythmias
How are cardiac arrhythmias actually caused? We know that cardiac arrhythmias occur in PLN and that PLN regulates calcium. Calcium is important for the conversion of an electrical signal into…
PLN mouse heart I: Changes in calcium currents (Haghighi, 2021)
In a series of three articles, we will discuss the mechanism behind cardiac arrhythmias. In these three articles, we discuss three studies in which cardiac arrhythmias were investigated at the…
I-1c: A potential treatment for PLN-R14del becomes available to patients in clinical trials
The mission of the PLN Foundation is crystal clear: to find a safe, affordable and effective treatment for PLN R14del. A new development may offer hope: the experimental drug I-1c,…
Ride along and raise money for PLN research during Vuelta in Utrecht 2025! 🚴
On Sunday, August 31, 2025, Vuelta a Utrecht will take place. This is a tour in Spanish spheres, on Dutch soil. A wonderful moment when the Netherlands Heart Institute team…
Join research for guidance before, during and after pregnancy for female carriers of the PLN mutation
For this study, the UMCG (UMC Groningen) is asking for help from women who are carriers of the PLN gene mutation (p.(Arg14del) variant). With this research they want to learn…
The discovery of PLN-R14del in the Netherlands, by Van der Zwaag (2012 & 2013)
Original article: Zwaag Van der, 2012, Eur. Original article: Zwaag Van der, 2013, Neth. In a previous article, we described the discovery of PLN-R14del in Greek cardiac patients. In 2009,…
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