Thesis: “Recombinant Adeno-associated virus as a therapeutic therapy for PLN R14DEL patients”
Read here the thesis of Sam Biermans, a Biomedical Sciences student at Utrecht University. Under the guidance of Dr. Niels Bovenschen, Sam Biermans wrote her thesis on the current developments in virus therapy for PLN patients. It is a very clear, in-depth, and informative thesis for those interested. Her thesis mainly focuses on the adeno-associated […]
The Hearts Bank
The PLN Foundation is a co-initiator of this Hearts Bank. BIOMEDICAL BANK FOR HEARTS The Hearst Bank is a central biobank where heart tissue and medical data from deceased donors are stored and provided for scientific research. With this heart tissue, researchers can examine how a heart functions in the early stages of a disease […]
Crazy Ideas | 2017 – Present
As developments in the medical field progress rapidly, we aim to remain flexible with our research project and take advantage of new advancements. Therefore, our Foundation PLN organizes a “Crazy Ideas” session twice a year, nationally and internationally. During these sessions, we invite medical scientists to come up with ideas to make the disease caused […]
Basic Research
In order to find the right treatment method, it is essential for researchers to understand the functioning of the gene. What exactly happens with the mutation, what goes wrong, and where does it go wrong? What occurs first, and what does the chain reaction look like afterwards? Why does one carrier become ill while another […]
Solutions
There is a focus on three solutions: Correction of the specific PLN mutation in the DNA In this research direction, the focus is on correcting the specific mutation in the DNA, which lies coiled up in the cell nucleus. This technique shows great promise but is also the most complex. Correcting the mutation can be […]
CURE-PlaN project | 2019- heden
In mid-2018, Fondation Leducq granted six million USD for a comprehensive international research plan focused entirely on PLN, known as the CURE-PLaN project. This project officially started on January 1, 2019. It comprises a transatlantic team brought together by our Foundation, including researchers from UMC Groningen, Amsterdam UMC, UMC Utrecht, New York Mount Sinai Hospital, […]
Transatlantic Project | 2017 – present
In the first years after the establishment of the Genetic Cardiomyopathy PLN Foundation in 2012, the focus was on gaining insight into the disease and acquiring knowledge. Particularly, medical scientific research in the Netherlands was initiated and financially supported. Subsequently, a worldwide survey was conducted to identify existing knowledge and ongoing research on the PLN […]