The PLN Mouse Heart II: Tickak tikKRAK, how problems in a PLN heart can lead to arrhythmias
How are cardiac arrhythmias actually caused? We know that cardiac arrhythmias occur in PLN and that PLN regulates calcium. Calcium is important for the conversion of an electrical signal into the contraction of the heart. Thus, it is plausible that the two are related. In this article, we discuss a study that looked very closely […]
PLN mouse heart I: Changes in calcium currents (Haghighi, 2021)
In a series of three articles, we will discuss the mechanism behind cardiac arrhythmias. In these three articles, we discuss three studies in which cardiac arrhythmias were investigated at the level of single cells and of the whole heart, and then a study of a treatment. The so-called human mouse model was used for these […]
The discovery of PLN-R14del in the Netherlands, by Van der Zwaag (2012 & 2013)
Original article: Zwaag Van der, 2012, Eur. Original article: Zwaag Van der, 2013, Neth. In a previous article, we described the discovery of PLN-R14del in Greek cardiac patients. In 2009, an article appeared describing a German family where the mutation was identified. Following this news, Groningen doctors investigated whether the mutation might also occur in […]
The discovery of PLN-R14del – by Haghighi 2006
Original article: Haghighi, 2006, PNAS A mutation in the human phospholamban gene, deleting arginine 14, results in lethal hereditary cardiomyopathy The first scientific article on the R14del mutation appeared in 2006. By 2006, two mutations in PLN were known to also cause heart problems, but with different severity. Furthermore, researchers knew that PLN was very […]